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Nutr Cancer. 2005;53(1):117-25.
Effect of dried plums on colon cancer risk factors in rats.
Yang Y, Gallaher DD.
Author information
Abstract
Dried plums (that is, prunes) are a fruit that show promise as a food to lower colon cancer risk, based on their high content of dietary fiber and polyphenolics. In this study, we have examined the effect of diets containing dried plums on the number of colonic precancerous lesions (aberrant crypts, ACs), fecal bile acid concentration, and cecal bacterial enzyme activities related to colon cancer risk. Rats were fed one of four diets: a basal diet (a modified AIN-93G diet), a low-concentration dried plum diet (LCDP, 4.75% dried plum powder), a high-concentration dried plum diet (HCDP, 9.5% dried plum powder), or a diet matched to the carbohydrate content of the HCDP diet (CH-M) for 10 days. All animals were then administered azoxymethane (15 mg/kg, s.c., given two times, 1 wk apart) and fed their respective diets for 9 additional weeks. The number of AC foci (ACF), large ACF (>3 AC/ACF), or ACF multiplicity (AC/ACF) did not differ among the four groups. When compared with the basal diet, rats fed the LCDP diet had significantly lower concentrations of total fecal bile acids, deoxycholic acid, and hyodeoxycholic acid. Rats fed the HCDP diet had significantly lower fecal concentrations of lithocholic acid and hyodeoxycholic acid. The LCDP and HCDP diets significantly decreased the cecal activity of 7alpha-dehydroxylase, and the LCDP also had lower beta-glucuronidase activity. The LCDP, HCDP, and CH-M groups had significantly greater cecal nitroreductase activities than the basal group. There was a significant correlation between 7alpha-dehydroxylase activity and fecal lithocholic acid concentration. Compared with the basal diet, both the LCDP and HCDP diets greatly increased cecal supernatant oxygen radical absorbance capacity (ORAC). These results suggest that, although dried plums did not reduce ACF number, they favorably altered other colon cancer risk factors.
Plum Cancer Prevention
Plum Health Benefits
The ability of plum and prune (dried plum) to increase absorption of iron into the body has also been documented in published research. This ability of plum and prune to make iron more available may be related to the vitamin C content of this fruit. Plums stimulate the bowel movement. Their function is that of an antioxidant and is of much benefit to the body. Since plums are rich in antioxidants, they provide protection from superoxide anion radical and also prevent damage to our neurons and fats that form a part of our cell membranes. Consumption of plums helps in the production and absorption of iron in the body, thus leading to better blood circulation, which further leads to the growth of healthy tissues. Regular consumption of plums can prevent macular degeneration and any other infection of the eye, in the long run. Your eyes will be healthy and strong for long time and you can also retain a sharp eye-sight.
Plums Anti-Cancer Agents
Plums, even their dried form known as ‘prunes’ are high in unique phytonutrients called neochlorogenicand chlorogenic acid. These phenolic compounds are the ones that caught the attention of scientists at Texas AgriLife Research. In their lab studies, when the phenols from plums got together with breast cancer cells, the malignant cells were killed. Researchers were happy with those results, but even more pleased about the response from healthy cells. “These extracts killed the cancer cells but not the normal cells,” said Dr. Luis Cisneros-Zevallos, who worked on the study. Plums’ extract are chosen because of their particularly high phenolic content. Chlorogenic and neochlorogenic phenols from these peaches and plums were found to kill breast cancer cells, without harming healthy cells nearby.
Even when scientists tested these fruit phenols on the most aggressive types of breast cancer cells, the cancer died and the healthy cells were unaffected. That’s a dream come true for breast cancer patients that may require chemotherapy – a systemic treatment that affects every cell in the body.
Plum Research Links
Several studies show that prunes are for osteoporosis prevention.
www.elements4health.com/plums.html
Effect of dried plums on colon cancer risk factors in rats.
www.ncbi.nlm.nih.gov/pubmed/16351514
Prunes for Osteoporosis Prevention
Several studies have demonstrated that dried plums, or prunes, which contain high amounts of polyphenols, can restore bone mass and structure.